Profiling Cys34 Adducts of Human Serum Albumin by Fixed-Step Selected Reaction Monitoring
نویسندگان
چکیده
منابع مشابه
Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation.
Protein N-homocysteinylation involves a post-translational modification by homocysteine (Hcy)-thiolactone. In humans, about 70% of circulating Hcy is N-linked to blood proteins, mostly to hemoglobin and albumin. It was unclear what protein site(s) were prone to Hcy attachment and how N-linked Hcy affected protein function. Here we show that Lys(525) is a predominant site of N-homocysteinylation...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2011
ISSN: 1535-9476
DOI: 10.1074/mcp.m110.004606